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Assay Detail

CHEMBL944271

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum TM91C235 by [3H]hypoxanthine uptake
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.
Lee PJ, Bhonsle JB, Gaona HW, Huddler DP, Heady TN, Kreishman-Deitrick M, Bhattacharjee A, McCalmont WF, Gerena L, Lopez-Sanchez M, Roncal NE, Hudson TH, Johnson JD, Prigge ST, Waters NC.
J Med Chem (2009) 52 : 952 -963
PubMed 19191586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.91 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6967 1 5.85
CHEMBL454221 1 5.47
CHEMBL490099 1 5.35
CHEMBL449180 1 5.28
CHEMBL524094 1 4.50
CHEMBL491675 1 4.49
CHEMBL462375 1 4.22
CHEMBL489104 1 4.09
CHEMBL522958 1 -
CHEMBL490686 1 -
CHEMBL453261 1 -
CHEMBL509952 1 -
CHEMBL462553 1 -
CHEMBL499767 1 -
CHEMBL489703 1 -
CHEMBL490100 1 -
CHEMBL489904 1 -
CHEMBL489905 1 -
CHEMBL489105 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6967 IC50 = 1400.0 nM 5.85
CHEMBL454221 IC50 = 3400.0 nM 5.47
CHEMBL490099 IC50 = 4500.0 nM 5.35
CHEMBL449180 IC50 = 5300.0 nM 5.28
CHEMBL524094 IC50 = 31700.0 nM 4.50
CHEMBL491675 IC50 = 32700.0 nM 4.49
CHEMBL462375 IC50 = 60500.0 nM 4.22
CHEMBL489104 IC50 = 80800.0 nM 4.09
CHEMBL522958 IC50 - -
CHEMBL490686 IC50 - -
CHEMBL453261 IC50 = 111900.0 nM -
CHEMBL509952 IC50 - -
CHEMBL462553 IC50 > 230200.0 nM -
CHEMBL499767 IC50 - -
CHEMBL489703 IC50 - -
CHEMBL490100 IC50 - -
CHEMBL489904 IC50 > 203700.0 nM -
CHEMBL489905 IC50 - -
CHEMBL489105 IC50 > 55300.0 nM -