Assay Detail
Functional
CHEMBL944289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 infected erythrocytes by LDH assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.27 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445526 | — | — | 1 | 6.52 |
| CHEMBL508289 | — | — | 1 | 5.92 |
| CHEMBL505741 | — | — | 1 | 5.92 |
| CHEMBL443598 | — | — | 1 | 5.68 |
| CHEMBL443659 | — | — | 1 | 5.33 |
| CHEMBL500849 | — | — | 1 | 5.29 |
| CHEMBL509526 | — | — | 1 | 5.29 |
| CHEMBL450692 | — | — | 1 | 5.16 |
| CHEMBL446833 | — | — | 1 | 5.10 |
| CHEMBL510614 | — | — | 1 | 5.07 |
| CHEMBL449452 | — | — | 1 | 4.88 |
| CHEMBL454552 | — | — | 1 | 4.85 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 4.80 |
| CHEMBL444211 | — | — | 1 | 4.66 |
| CHEMBL450166 | — | — | 1 | 4.59 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445526 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL508289 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL505741 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL443598 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL443659 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL500849 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL509526 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL450692 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL446833 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL510614 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL449452 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL454552 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL444211 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL450166 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 744100.0 | nM | - |