Assay Detail
Functional
CHEMBL944292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by alamar-blue assay
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.50 | 7.00 |
| IC90 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 2 | 7.00 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 2 | 5.46 |
| CHEMBL505741 | — | — | 2 | 5.30 |
| CHEMBL449452 | — | — | 2 | 5.13 |
| CHEMBL446833 | — | — | 2 | 5.11 |
| CHEMBL445526 | — | — | 2 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL505741 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL449452 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL446833 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL445526 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL505741 | — | IC90 | = | 16000.0 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | IC90 | = | 200.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC90 | = | 14700.0 | nM | - |
| CHEMBL449452 | — | IC90 | = | 18500.0 | nM | - |
| CHEMBL446833 | — | IC90 | = | 77100.0 | nM | - |
| CHEMBL445526 | — | IC90 | = | 80300.0 | nM | - |