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Assay Detail

CHEMBL944393

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of human MDA-MB-231 cell proliferation assessed as cell viability after 48 hrs by ATPlite assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.
Huang JW, Zhang Z, Wu B, Cellitti JF, Zhang X, Dahl R, Shiau CW, Welsh K, Emdadi A, Stebbins JL, Reed JC, Pellecchia M.
J Med Chem (2008) 51 : 7111 -7118
PubMed 18956862 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.79 4.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL458358 1 4.79
CHEMBL234346 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL458358 IC50 = 16400.0 nM 4.79
CHEMBL234346 IC50 > 50000.0 nM -