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Assay Detail

CHEMBL944416

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Functional
Cytotoxicity against human U251 RCB 0641 cells after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-251
Confidence 1 — Organism
Curated By Autocuration

Target

U-251 (CHEMBL615022)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and cytotoxic activities of usnic acid derivatives.
Bazin MA, Le Lamer AC, Delcros JG, Rouaud I, Uriac P, Boustie J, Corbel JC, Tomasi S.
Bioorg Med Chem (2008) 16 : 6860 -6866
PubMed 18558490 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.18 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44657 ETOPOSIDE 4.0 1 6.30
CHEMBL470280 1 5.36
CHEMBL511972 1 5.09
CHEMBL470901 1 4.90
CHEMBL461903 (-)-USNIC ACID 1 4.71
CHEMBL367881 (+)-USNIC ACID 1 4.71
CHEMBL470077 1 -
CHEMBL29392 DIAMINOOCTANE 1 -
CHEMBL23194 SPERMINE 0.5 1 -
CHEMBL19612 SPERMIDINE 3.0 1 -
CHEMBL46257 PUTRESCINE 3.0 1 -
CHEMBL471695 1 -
CHEMBL511151 1 -
CHEMBL470281 1 -
CHEMBL469474 1 -
CHEMBL469880 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44657 ETOPOSIDE IC50 = 500.0 nM 6.30
CHEMBL470280 IC50 = 4400.0 nM 5.36
CHEMBL511972 IC50 = 8200.0 nM 5.09
CHEMBL470901 IC50 = 12500.0 nM 4.90
CHEMBL461903 (-)-USNIC ACID IC50 = 19700.0 nM 4.71
CHEMBL367881 (+)-USNIC ACID IC50 = 19500.0 nM 4.71
CHEMBL470077 IC50 - -
CHEMBL29392 DIAMINOOCTANE IC50 - -
CHEMBL23194 SPERMINE IC50 - -
CHEMBL19612 SPERMIDINE IC50 - -
CHEMBL46257 PUTRESCINE IC50 - -
CHEMBL471695 IC50 - -
CHEMBL511151 IC50 - -
CHEMBL470281 IC50 - -
CHEMBL469474 IC50 > 100000.0 nM -
CHEMBL469880 IC50 > 100000.0 nM -