Assay Detail
Functional
CHEMBL944591
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Inhibition of A23187-induced 12-hydroxy-5,8,10-heptadecatrienoic acid formation in human polymorphonuclear leukocytes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.10 | 4.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249448 | — | — | 1 | 4.10 |
| CHEMBL249447 | — | — | 1 | - |
| CHEMBL177126 | — | — | 1 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
| CHEMBL393293 | CAFFEOYLMALIC ACID | — | 1 | - |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | - |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249448 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL249447 | — | IC50 | = | 902000.0 | nM | - |
| CHEMBL177126 | — | IC50 | = | 740000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | - | — | - | |
| CHEMBL393293 | CAFFEOYLMALIC ACID | IC50 | = | 796000.0 | nM | - |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | - | — | - | |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 459000.0 | nM | - |