Assay Detail
Functional
CHEMBL944667
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Antitumor activity against human K562 cells assessed as induction of cell death after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity and structure-activity relationships of four alpha-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.54 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231621 | — | — | 1 | 8.70 |
| CHEMBL113086 | — | — | 1 | 4.59 |
| CHEMBL231041 | — | — | 1 | 4.55 |
| CHEMBL109272 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231621 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL113086 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL231041 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL109272 | — | IC50 | = | 47500.0 | nM | 4.32 |