Assay Detail
Binding
CHEMBL944753
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Inhibition of MMP2
43
Total Activities
43
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.53 | 8.60 |
| Ki | 2 | 9.40 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103418 | — | — | 1 | 9.40 |
| CHEMBL180616 | — | — | 1 | 9.40 |
| CHEMBL400285 | — | — | 1 | 8.60 |
| CHEMBL251831 | — | — | 1 | 8.55 |
| CHEMBL253032 | — | — | 1 | 8.40 |
| CHEMBL429123 | — | — | 1 | 8.32 |
| CHEMBL398265 | — | — | 1 | 8.28 |
| CHEMBL254929 | — | — | 1 | 8.26 |
| CHEMBL254509 | — | — | 1 | 8.26 |
| CHEMBL399029 | — | — | 1 | 8.25 |
| CHEMBL398644 | — | — | 1 | 8.24 |
| CHEMBL253892 | — | — | 1 | 8.12 |
| CHEMBL430210 | — | — | 1 | 8.07 |
| CHEMBL252827 | — | — | 1 | 8.04 |
| CHEMBL400641 | — | — | 1 | 8.03 |
| CHEMBL253242 | — | — | 1 | 8.02 |
| CHEMBL429486 | — | — | 1 | 8.00 |
| CHEMBL398351 | — | — | 1 | 8.00 |
| CHEMBL253033 | — | — | 1 | 7.96 |
| CHEMBL400785 | — | — | 1 | 7.92 |
| CHEMBL254293 | — | — | 1 | 7.89 |
| CHEMBL253450 | — | — | 1 | 7.77 |
| CHEMBL252426 | — | — | 1 | 7.62 |
| CHEMBL400784 | — | — | 1 | 7.62 |
| CHEMBL401404 | — | — | 1 | 7.57 |
| CHEMBL398331 | — | — | 1 | 7.46 |
| CHEMBL428591 | — | — | 1 | 7.33 |
| CHEMBL254506 | — | — | 1 | 7.28 |
| CHEMBL252422 | — | — | 1 | 7.21 |
| CHEMBL399565 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103418 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL180616 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL400285 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL251831 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL253032 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL429123 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL398265 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL254929 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL254509 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL399029 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL398644 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL253892 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL430210 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL252827 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL400641 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL253242 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL429486 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL398351 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL253033 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL400785 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL254293 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL253450 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL400784 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL252426 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL401404 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL398331 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL428591 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL254506 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL252422 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL399565 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL252022 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL400192 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL254718 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL252826 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL398350 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL400193 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL252823 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL400445 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL399566 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL252021 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL251827 | — | IC50 | = | 1318.0 | nM | 5.88 |
| CHEMBL251821 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL252020 | — | IC50 | > | 10000.0 | nM | - |