Assay Detail
Binding
CHEMBL944771
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Inhibition of HIV NL43 recombinant reverse transcriptase K103N mutant by scintillation proximity assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.69 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253018 | — | — | 1 | 8.05 |
| CHEMBL252405 | — | — | 1 | 7.70 |
| CHEMBL403784 | — | — | 1 | 7.60 |
| CHEMBL252406 | — | — | 1 | 7.51 |
| CHEMBL252608 | — | — | 1 | 7.38 |
| CHEMBL400045 | — | — | 1 | 7.32 |
| CHEMBL252609 | — | — | 1 | 7.21 |
| CHEMBL252607 | — | — | 1 | 7.03 |
| CHEMBL252810 | — | — | 1 | 6.96 |
| CHEMBL283950 | L-737126 | — | 1 | 6.94 |
| CHEMBL253016 | — | — | 1 | 6.82 |
| CHEMBL252811 | — | — | 1 | 6.82 |
| CHEMBL252603 | — | — | 1 | 6.77 |
| CHEMBL253017 | — | — | 1 | 6.66 |
| CHEMBL252407 | — | — | 1 | 6.58 |
| CHEMBL403783 | — | — | 1 | 6.55 |
| CHEMBL252812 | — | — | 1 | 6.55 |
| CHEMBL398419 | — | — | 1 | 6.43 |
| CHEMBL403126 | — | — | 1 | 5.71 |
| CHEMBL252795 | — | — | 1 | 5.64 |
| CHEMBL264320 | — | — | 1 | 5.55 |
| CHEMBL401342 | — | — | 1 | 5.09 |
| CHEMBL253629 | — | — | 1 | 5.00 |
| CHEMBL252805 | — | — | 1 | - |
| CHEMBL443318 | — | — | 1 | - |
| CHEMBL400903 | — | — | 1 | - |
| CHEMBL253638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253018 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL252405 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL403784 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL252406 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL252608 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL400045 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL252609 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL252607 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL252810 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL283950 | L-737126 | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL253016 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL252811 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL252603 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL253017 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL252407 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL403783 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL252812 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL398419 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL403126 | — | IC50 | = | 1963.0 | nM | 5.71 |
| CHEMBL252795 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL264320 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL401342 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL253629 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL252805 | — | IC50 | - | — | - | |
| CHEMBL443318 | — | IC50 | - | — | - | |
| CHEMBL400903 | — | IC50 | - | — | - | |
| CHEMBL253638 | — | IC50 | - | — | - |