Assay Detail
Functional
CHEMBL944784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cholesterol synthesis in rat hepatocyte
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 9.00 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438884 | — | — | 1 | 9.66 |
| CHEMBL403430 | — | — | 1 | 9.60 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 9.57 |
| CHEMBL252855 | — | — | 1 | 9.43 |
| CHEMBL252854 | — | — | 1 | 9.40 |
| CHEMBL437790 | — | — | 1 | 9.35 |
| CHEMBL437795 | — | — | 1 | 9.33 |
| CHEMBL429487 | — | — | 1 | 9.30 |
| CHEMBL403646 | — | — | 1 | 9.24 |
| CHEMBL437783 | — | — | 1 | 9.17 |
| CHEMBL404672 | — | — | 1 | 9.16 |
| CHEMBL253055 | — | — | 1 | 9.12 |
| CHEMBL401949 | — | — | 1 | 9.10 |
| CHEMBL252657 | — | — | 1 | 9.02 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 9.00 |
| CHEMBL253054 | — | — | 1 | 8.96 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 8.89 |
| CHEMBL401950 | — | — | 1 | 8.85 |
| CHEMBL1477 | CERIVASTATIN | 4.0 | 1 | 8.77 |
| CHEMBL404671 | — | — | 1 | 8.74 |
| CHEMBL251863 | — | — | 1 | 8.60 |
| CHEMBL253258 | — | — | 1 | 8.57 |
| CHEMBL402622 | — | — | 1 | 8.52 |
| CHEMBL253053 | — | — | 1 | 8.48 |
| CHEMBL265899 | — | — | 1 | 8.30 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438884 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL403430 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL252855 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL252854 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL437790 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL437795 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL429487 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL403646 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL437783 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL404672 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL253055 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL401949 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL252657 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL253054 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL401950 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL404671 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL251863 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL253258 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL402622 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL253053 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL265899 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 17.0 | nM | 7.77 |