Assay Detail
Binding
CHEMBL944827
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Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cells
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-Aminoindanes as novel motif with potential atypical antipsychotic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.69 | 7.46 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398744 | — | — | 1 | 7.46 |
| CHEMBL253024 | — | — | 1 | 7.46 |
| CHEMBL442290 | — | — | 1 | 7.11 |
| CHEMBL252816 | — | — | 1 | 7.00 |
| CHEMBL252429 | — | — | 1 | 6.87 |
| CHEMBL252230 | — | — | 1 | 6.86 |
| CHEMBL398711 | — | — | 1 | 6.84 |
| CHEMBL251834 | — | — | 1 | 6.82 |
| CHEMBL253022 | — | — | 1 | 6.79 |
| CHEMBL253439 | — | — | 1 | 6.78 |
| CHEMBL252031 | — | — | 1 | 6.74 |
| CHEMBL398618 | — | — | 1 | 6.71 |
| CHEMBL400235 | — | — | 1 | 6.71 |
| CHEMBL253878 | — | — | 1 | 6.70 |
| CHEMBL252430 | — | — | 1 | 6.70 |
| CHEMBL398525 | — | — | 1 | 6.66 |
| CHEMBL252228 | — | — | 1 | 6.57 |
| CHEMBL253233 | — | — | 1 | 6.57 |
| CHEMBL400236 | — | — | 1 | 6.56 |
| CHEMBL398619 | — | — | 1 | 6.45 |
| CHEMBL252201 | — | — | 1 | 6.29 |
| CHEMBL404000 | — | — | 1 | 6.21 |
| CHEMBL252818 | — | — | 1 | 6.05 |
| CHEMBL252030 | — | — | 1 | 5.66 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398744 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL253024 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL442290 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL252816 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL252429 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL252230 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL398711 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL251834 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL253022 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL253439 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL252031 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL398618 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL400235 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL253878 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL252430 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL398525 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL252228 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL253233 | — | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL400236 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL398619 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL252201 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL404000 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL252818 | — | Ki | = | 885.0 | nM | 6.05 |
| CHEMBL252030 | — | Ki | = | 2202.0 | nM | 5.66 |
| CHEMBL708 | ZIPRASIDONE | Activity | - | — | - |