Assay Detail
Functional
CHEMBL944856
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human RPMI8226 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimitotic quinoid triterpenes from Maytenus chuchuhuasca.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.55 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.52 |
| CHEMBL432519 | TINGENONE | — | 1 | 5.16 |
| CHEMBL54804 | PRISTIMERIN | — | 1 | 4.78 |
| CHEMBL402975 | TINGENIN B | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL301982 | CELASTROL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL432519 | TINGENONE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL54804 | PRISTIMERIN | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL402975 | TINGENIN B | IC50 | = | 18300.0 | nM | 4.74 |