Assay Detail
Binding
CHEMBL945014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE4 expressed in SF9 cells
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.40 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402953 | — | — | 1 | 9.10 |
| CHEMBL253083 | — | — | 2 | 9.10 |
| CHEMBL252469 | — | — | 1 | 9.00 |
| CHEMBL251882 | — | — | 1 | 8.96 |
| CHEMBL252490 | — | — | 1 | 8.82 |
| CHEMBL403744 | — | — | 1 | 8.82 |
| CHEMBL403065 | — | — | 1 | 8.77 |
| CHEMBL253082 | — | — | 1 | 8.72 |
| CHEMBL252089 | — | — | 1 | 8.72 |
| CHEMBL252887 | — | — | 1 | 8.66 |
| CHEMBL401663 | — | — | 1 | 8.59 |
| CHEMBL403977 | — | — | 1 | 8.57 |
| CHEMBL403546 | — | — | 1 | 8.54 |
| CHEMBL252491 | — | — | 1 | 8.52 |
| CHEMBL372575 | — | — | 1 | 8.52 |
| CHEMBL254518 | — | — | 1 | 8.38 |
| CHEMBL252886 | — | — | 1 | 8.34 |
| CHEMBL252687 | — | — | 1 | 8.25 |
| CHEMBL436847 | — | — | 1 | 8.17 |
| CHEMBL252885 | — | — | 1 | 8.14 |
| CHEMBL252686 | — | — | 1 | 8.06 |
| CHEMBL252090 | — | — | 1 | 8.00 |
| CHEMBL252287 | — | — | 1 | 7.92 |
| CHEMBL252088 | — | — | 1 | 7.66 |
| CHEMBL251883 | — | — | 1 | 7.52 |
| CHEMBL252685 | — | — | 1 | 7.41 |
| CHEMBL252489 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402953 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL253083 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL252469 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL251882 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL253083 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL252490 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL403744 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL403065 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL253082 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL252089 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL252887 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL401663 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL403977 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL403546 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL252491 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL372575 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL254518 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL252886 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL252687 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL436847 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL252885 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL252686 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL252090 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL252287 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL252088 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL251883 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL252685 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL252489 | — | IC50 | = | 107.0 | nM | 6.97 |