Assay Detail
Binding
CHEMBL945080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin B
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.99 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399733 | — | — | 1 | 7.00 |
| CHEMBL252784 | — | — | 1 | 6.36 |
| CHEMBL399361 | — | — | 1 | 6.02 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 5.99 |
| CHEMBL252582 | — | — | 1 | 5.82 |
| CHEMBL252179 | — | — | 1 | 5.46 |
| CHEMBL437501 | — | — | 1 | 5.28 |
| CHEMBL252571 | — | — | 1 | - |
| CHEMBL398910 | — | — | 1 | - |
| CHEMBL252581 | — | — | 1 | - |
| CHEMBL252383 | — | — | 1 | - |
| CHEMBL428417 | — | — | 1 | - |
| CHEMBL252382 | — | — | 1 | - |
| CHEMBL250294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399733 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL252784 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL399361 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 1034.0 | nM | 5.99 |
| CHEMBL252582 | — | IC50 | = | 1528.0 | nM | 5.82 |
| CHEMBL252179 | — | IC50 | = | 3453.0 | nM | 5.46 |
| CHEMBL437501 | — | IC50 | = | 5239.0 | nM | 5.28 |
| CHEMBL252571 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL398910 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL252581 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL252383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL428417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL252382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL250294 | — | IC50 | > | 10000.0 | nM | - |