Assay Detail

CHEMBL945089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of rabbit cathepsin K

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Cathepsin K (CHEMBL3349) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Cathepsin K (CHEMBL3349) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cathepsin K

CHEMBL3349

Anchored from Assay target.

Protein identity Cathepsin K

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	9 — Direct single protein target
Curated By	Intermediate

Target

Cathepsin K (CHEMBL3349) ↗

Type	SINGLE PROTEIN
Organism	Oryctolagus cuniculus

Publication

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong LT, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T, Li CS, Massé F, McKay DJ, Nicoll-Griffith DA, Oballa RM, Palmer JT, Percival MD, Riendeau D, Robichaud J, Rodan GA, Rodan SB, Seto C, Thérien M, Truong VL, Venuti MC, Wesolowski G, Young RN, Zamboni R, Black WC.
Bioorg Med Chem Lett (2008) 18 : 923 -928
PubMed 18226527 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	4	8.99	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL203665	RELACATIB	2.0	1	9.30
CHEMBL437501	—	—	1	9.10
CHEMBL481611	ODANACATIB	3.0	1	9.00
CHEMBL371064	BALICATIB	2.0	1	8.57

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL203665	RELACATIB	IC50	=	0.5	nM	9.30
CHEMBL437501	—	IC50	=	0.8	nM	9.10
CHEMBL481611	ODANACATIB	IC50	=	1.0	nM	9.00
CHEMBL371064	BALICATIB	IC50	=	2.7	nM	8.57