Assay Detail
Functional
CHEMBL945090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bone resorption in rabbit osteoclast
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437501 | — | — | 1 | 7.89 |
| CHEMBL203665 | RELACATIB | 2.0 | 1 | 7.82 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 7.64 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437501 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL203665 | RELACATIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL371064 | BALICATIB | IC50 | = | 97.0 | nM | 7.01 |