Assay Detail
Binding
CHEMBL945091
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Inhibition of cathepsin B in human HepG2 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.59 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | 2.0 | 1 | 7.85 |
| CHEMBL371064 | BALICATIB | 2.0 | 1 | 7.21 |
| CHEMBL481611 | ODANACATIB | 3.0 | 1 | 5.98 |
| CHEMBL437501 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203665 | RELACATIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL371064 | BALICATIB | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL481611 | ODANACATIB | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL437501 | — | IC50 | = | 4807.0 | nM | 5.32 |