Assay Detail
Functional
CHEMBL945109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as blockade of capsaicin-induced receptor activation by FLIPR assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441472 | — | — | 1 | 8.30 |
| CHEMBL104028 | — | — | 1 | 8.30 |
| CHEMBL254984 | — | — | 1 | 7.50 |
| CHEMBL254778 | — | — | 1 | 7.19 |
| CHEMBL403013 | — | — | 1 | 7.16 |
| CHEMBL254779 | — | — | 1 | 7.05 |
| CHEMBL186411 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441472 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL104028 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL254984 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL254778 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL403013 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL254779 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL186411 | — | IC50 | = | 103.0 | nM | 6.99 |