Assay Detail
Binding
CHEMBL945139
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Inhibition of MMP2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.71 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401471 | — | — | 1 | 5.87 |
| CHEMBL251994 | — | — | 1 | 5.72 |
| CHEMBL401263 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401471 | — | Ki | = | 1357.0 | nM | 5.87 |
| CHEMBL251994 | — | Ki | = | 1920.0 | nM | 5.72 |
| CHEMBL401263 | — | Ki | = | 2800.0 | nM | 5.55 |