Assay Detail
Binding
CHEMBL945289
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Displacement of [3H]DTG from sigma2 receptor in rat liver membrane
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.98 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516814 | — | — | 1 | 7.80 |
| CHEMBL461956 | — | — | 1 | 7.73 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.46 |
| CHEMBL129530 | — | — | 1 | 7.45 |
| CHEMBL473129 | — | — | 3 | 6.60 |
| CHEMBL473546 | — | — | 1 | 6.50 |
| CHEMBL473547 | — | — | 1 | 6.23 |
| CHEMBL473751 | — | — | 1 | - |
| CHEMBL473548 | — | — | 1 | - |
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | - |
| CHEMBL461783 | — | — | 1 | - |
| CHEMBL510679 | — | — | 1 | - |
| CHEMBL462659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516814 | — | Ki | = | 15.83 | nM | 7.80 |
| CHEMBL461956 | — | Ki | = | 18.5 | nM | 7.73 |
| CHEMBL20730 | VESAMICOL | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL129530 | — | Ki | = | 35.9 | nM | 7.45 |
| CHEMBL473129 | — | Ki | = | 251.3 | nM | 6.60 |
| CHEMBL473129 | — | Ki | = | 277.93 | nM | 6.56 |
| CHEMBL473546 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL473129 | — | Ki | = | 319.23 | nM | 6.50 |
| CHEMBL473547 | — | Ki | = | 592.6 | nM | 6.23 |
| CHEMBL473751 | — | Ki | - | — | - | |
| CHEMBL473548 | — | Ki | - | — | - | |
| CHEMBL87379 | BENZOVESAMICOL | Ki | - | — | - | |
| CHEMBL461783 | — | Ki | - | — | - | |
| CHEMBL510679 | — | Ki | - | — | - | |
| CHEMBL462659 | — | Ki | - | — | - |