Assay Detail
Binding
CHEMBL945304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]alpha-bungarotoxin form alpha7 nAChR in rat cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.40 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472243 | — | — | 1 | 8.87 |
| CHEMBL462846 | — | — | 1 | 8.39 |
| CHEMBL470573 | — | — | 1 | 7.70 |
| CHEMBL470367 | — | — | 1 | 7.60 |
| CHEMBL463229 | — | — | 1 | 7.30 |
| CHEMBL470366 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472243 | — | Ki | = | 1.36 | nM | 8.87 |
| CHEMBL462846 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL470573 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL470367 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL463229 | — | Ki | = | 50.5 | nM | 7.30 |
| CHEMBL470366 | — | Ki | = | 28000.0 | nM | 4.55 |