Assay Detail
Binding
CHEMBL945310
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Inhibition of CDK2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.94 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453217 | — | — | 1 | 7.00 |
| CHEMBL470780 | — | — | 1 | 5.96 |
| CHEMBL485731 | — | — | 1 | 5.82 |
| CHEMBL485730 | — | — | 1 | 5.82 |
| CHEMBL470175 | — | — | 1 | 5.78 |
| CHEMBL511811 | — | — | 1 | 5.62 |
| CHEMBL471819 | — | — | 1 | 5.61 |
| CHEMBL512172 | — | — | 1 | - |
| CHEMBL475254 | — | — | 1 | - |
| CHEMBL451450 | — | — | 1 | - |
| CHEMBL486751 | — | — | 1 | - |
| CHEMBL475249 | — | — | 1 | - |
| CHEMBL471727 | — | — | 1 | - |
| CHEMBL511670 | — | — | 1 | - |
| CHEMBL475570 | — | — | 1 | - |
| CHEMBL472478 | — | — | 1 | - |
| CHEMBL471776 | — | — | 1 | - |
| CHEMBL512319 | — | — | 1 | - |
| CHEMBL473229 | — | — | 1 | - |
| CHEMBL509161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453217 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL470780 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL485731 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL485730 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL470175 | — | Ki | = | 1652.0 | nM | 5.78 |
| CHEMBL511811 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL471819 | — | Ki | = | 2452.0 | nM | 5.61 |
| CHEMBL512172 | — | Ki | > | 3330.0 | nM | - |
| CHEMBL475254 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL451450 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL486751 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL475249 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL471727 | — | Ki | > | 2270.0 | nM | - |
| CHEMBL511670 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL475570 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL472478 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL471776 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL512319 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL473229 | — | Ki | > | 3330.0 | nM | - |
| CHEMBL509161 | — | Ki | > | 5000.0 | nM | - |