Assay Detail
Binding
CHEMBL945313
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Inhibition of ZAP70
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.13 | 6.62 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512172 | — | — | 1 | 6.62 |
| CHEMBL511670 | — | — | 1 | 6.57 |
| CHEMBL472478 | — | — | 1 | 6.50 |
| CHEMBL470780 | — | — | 1 | 6.39 |
| CHEMBL509161 | — | — | 1 | 6.38 |
| CHEMBL511811 | — | — | 1 | 6.35 |
| CHEMBL471727 | — | — | 1 | 6.25 |
| CHEMBL485730 | — | — | 1 | 6.17 |
| CHEMBL475254 | — | — | 1 | 6.17 |
| CHEMBL470175 | — | — | 1 | 6.12 |
| CHEMBL485731 | — | — | 1 | 6.12 |
| CHEMBL471776 | — | — | 1 | 6.05 |
| CHEMBL486751 | — | — | 1 | 6.00 |
| CHEMBL453217 | — | — | 1 | 5.99 |
| CHEMBL451450 | — | — | 1 | 5.94 |
| CHEMBL473229 | — | — | 1 | 5.82 |
| CHEMBL471819 | — | — | 1 | 5.81 |
| CHEMBL512319 | — | — | 1 | 5.67 |
| CHEMBL475249 | — | — | 1 | 5.46 |
| CHEMBL475570 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512172 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL511670 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL472478 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL470780 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL509161 | — | Ki | = | 419.1 | nM | 6.38 |
| CHEMBL511811 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL471727 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL485730 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL475254 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL470175 | — | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL485731 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL471776 | — | Ki | = | 891.0 | nM | 6.05 |
| CHEMBL486751 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL453217 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL451450 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL473229 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL471819 | — | Ki | = | 1551.0 | nM | 5.81 |
| CHEMBL512319 | — | Ki | = | 2145.0 | nM | 5.67 |
| CHEMBL475249 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL475570 | — | Activity | - | — | - |