Assay Detail
Binding
CHEMBL945372
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Inhibition of HTLV1 protease L40I mutant
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human T-cell leukemia virus type I |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.89 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444457 | — | — | 1 | 7.13 |
| CHEMBL447901 | — | — | 1 | 7.11 |
| CHEMBL509959 | — | — | 1 | 7.09 |
| CHEMBL499166 | — | — | 1 | 7.08 |
| CHEMBL499295 | — | — | 1 | 7.08 |
| CHEMBL510927 | — | — | 1 | 7.08 |
| CHEMBL448634 | — | — | 1 | 7.07 |
| CHEMBL448879 | — | — | 1 | 7.07 |
| CHEMBL502681 | — | — | 1 | 7.06 |
| CHEMBL395309 | — | — | 1 | 7.06 |
| CHEMBL508842 | — | — | 1 | 7.05 |
| CHEMBL501590 | — | — | 1 | 7.03 |
| CHEMBL508665 | — | — | 1 | 7.03 |
| CHEMBL502067 | — | — | 1 | 7.02 |
| CHEMBL453683 | — | — | 1 | 7.01 |
| CHEMBL501813 | — | — | 1 | 7.01 |
| CHEMBL454992 | — | — | 1 | 7.01 |
| CHEMBL447599 | — | — | 1 | 7.01 |
| CHEMBL447037 | — | — | 1 | 6.99 |
| CHEMBL499480 | — | — | 1 | 6.99 |
| CHEMBL509068 | — | — | 1 | 6.98 |
| CHEMBL446309 | — | — | 1 | 6.98 |
| CHEMBL500319 | — | — | 1 | 6.97 |
| CHEMBL509838 | — | — | 1 | 6.97 |
| CHEMBL507639 | — | — | 1 | 6.97 |
| CHEMBL446908 | — | — | 1 | 6.97 |
| CHEMBL474450 | — | — | 1 | 6.95 |
| CHEMBL503921 | — | — | 1 | 6.95 |
| CHEMBL508597 | — | — | 1 | 6.91 |
| CHEMBL448997 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444457 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL447901 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL509959 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL499166 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL499295 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL510927 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL448634 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL448879 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL502681 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL395309 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL508842 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL501590 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL508665 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL502067 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL447599 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL453683 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL454992 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL501813 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL447037 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL499480 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL509068 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL446309 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL446908 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL509838 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL500319 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL507639 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL474450 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL503921 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL508597 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL448997 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL450719 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL504064 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL451100 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL500845 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL499167 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL500109 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL500846 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL445814 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL509290 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL233025 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL447735 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL500881 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL499979 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL503945 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL448086 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL508981 | — | IC50 | = | 659.0 | nM | 6.18 |
| CHEMBL446970 | — | IC50 | = | 928.0 | nM | 6.03 |