Assay Detail
Functional
CHEMBL945400
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum TM6 in human erythrocytes by [3H]hypoxanthine uptake
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.97 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.82 |
| CHEMBL527655 | — | — | 1 | 5.05 |
| CHEMBL488829 | — | — | 1 | 4.64 |
| CHEMBL487275 | — | — | 1 | 4.45 |
| CHEMBL488663 | — | — | 1 | 4.44 |
| CHEMBL488491 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL527655 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL488829 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL487275 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL488663 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL488491 | — | IC50 | = | 36000.0 | nM | 4.44 |