Assay Detail
Binding
CHEMBL945401
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Inhibition of Plasmodium falciparum recombinant falcipain-2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.13 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486232 | — | — | 1 | 8.70 |
| CHEMBL488829 | — | — | 1 | 4.96 |
| CHEMBL487275 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486232 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL488829 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL487275 | — | IC50 | = | 19000.0 | nM | 4.72 |