Assay Detail
Functional
CHEMBL945435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at PTH/PTH-related peptide receptor expressed in HKRK-B28 cells assessed as inhibition of DPC-AJ1951-induced cAMP production
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HKRK-B28 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Parathyroid hormone/parathyroid hormone-related peptide receptor (CHEMBL1793) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.24 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515170 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515170 | — | IC50 | = | 5780.0 | nM | 5.24 |