Assay Detail
ADMET
CHEMBL945571
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Cytotoxicity against human KB cells by WST1 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.46 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.25 |
| CHEMBL501933 | SUNGUCINE | — | 1 | 5.21 |
| CHEMBL524656 | ISOSUNGUCINE | — | 1 | 5.05 |
| CHEMBL490322 | USAMBARENSINE | — | 1 | 5.01 |
| CHEMBL507761 | — | — | 1 | 4.79 |
| CHEMBL501860 | STRYCHNOGUCINE B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL501933 | SUNGUCINE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL524656 | ISOSUNGUCINE | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL490322 | USAMBARENSINE | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL507761 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL501860 | STRYCHNOGUCINE B | IC50 | > | 15000.0 | nM | - |