Assay Detail
Binding
CHEMBL945609
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Inhibition of [3H]NE uptake at human NET EL2 chimera mutant expressed in african green monkey COS1 cells after 48 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.97 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 9.13 |
| CHEMBL503461 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | IC50 | = | 0.7413 | nM | 9.13 |
| CHEMBL503461 | — | IC50 | = | 158.49 | nM | 6.80 |