Assay Detail
Functional
CHEMBL945689
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Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.94 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1753 | CLINDAMYCIN | 4.0 | 1 | 8.51 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 7.51 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.89 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 6.68 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 6.28 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1753 | CLINDAMYCIN | IC50 | = | 3.12 | nM | 8.51 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1750.0 | nM | 5.76 |