Assay Detail
Binding
CHEMBL945869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant mPGES1
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.90 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412099 | — | — | 1 | 9.00 |
| CHEMBL180650 | — | — | 1 | 8.52 |
| CHEMBL408218 | — | — | 1 | 8.05 |
| CHEMBL411327 | — | — | 1 | 7.92 |
| CHEMBL406392 | — | — | 1 | 7.77 |
| CHEMBL408965 | — | — | 1 | 7.72 |
| CHEMBL270094 | — | — | 1 | 7.68 |
| CHEMBL270347 | — | — | 1 | 7.44 |
| CHEMBL270095 | — | — | 1 | 7.35 |
| CHEMBL406679 | — | — | 1 | 7.33 |
| CHEMBL405474 | — | — | 1 | 7.29 |
| CHEMBL270508 | — | — | 1 | 7.14 |
| CHEMBL271956 | — | — | 1 | 7.12 |
| CHEMBL270718 | — | — | 1 | 7.06 |
| CHEMBL270348 | — | — | 1 | 7.00 |
| CHEMBL272424 | — | — | 1 | 6.85 |
| CHEMBL273089 | — | — | 1 | 6.48 |
| CHEMBL407548 | — | — | 1 | 6.39 |
| CHEMBL261386 | — | — | 1 | 6.28 |
| CHEMBL411326 | — | — | 1 | 6.25 |
| CHEMBL272858 | — | — | 1 | 6.16 |
| CHEMBL272184 | — | — | 1 | 6.15 |
| CHEMBL260525 | — | — | 1 | 5.89 |
| CHEMBL270507 | — | — | 1 | 5.70 |
| CHEMBL261604 | — | — | 1 | 5.60 |
| CHEMBL270719 | — | — | 1 | 5.18 |
| CHEMBL405697 | — | — | 1 | 5.10 |
| CHEMBL261385 | — | — | 1 | - |
| CHEMBL399902 | — | — | 1 | - |
| CHEMBL270702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412099 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL180650 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL408218 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL411327 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL406392 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL408965 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL270094 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL270347 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL270095 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL406679 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL405474 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL270508 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL271956 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL270718 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL270348 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL272424 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL273089 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL407548 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL261386 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL411326 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL272858 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL272184 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL260525 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL270507 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL261604 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL270719 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL405697 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL436640 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL403987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL260527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL269896 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL269895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL21156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL270702 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL399902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL261385 | — | IC50 | > | 10000.0 | nM | - |