Assay Detail
Functional
CHEMBL945870
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Inhibition of IL-1-beta-stimulated PGE2 production in human A549 cells in presence of 50% fetal bovine serum
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.82 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408218 | — | — | 1 | 6.48 |
| CHEMBL412099 | — | — | 1 | 6.38 |
| CHEMBL261386 | — | — | 1 | 6.25 |
| CHEMBL406392 | — | — | 1 | 6.24 |
| CHEMBL273089 | — | — | 1 | 6.19 |
| CHEMBL411327 | — | — | 1 | 6.12 |
| CHEMBL407548 | — | — | 1 | 6.09 |
| CHEMBL406679 | — | — | 1 | 5.96 |
| CHEMBL270094 | — | — | 1 | 5.96 |
| CHEMBL405474 | — | — | 1 | 5.80 |
| CHEMBL272424 | — | — | 1 | 5.80 |
| CHEMBL408965 | — | — | 1 | 5.80 |
| CHEMBL270347 | — | — | 1 | 5.66 |
| CHEMBL270095 | — | — | 1 | 5.57 |
| CHEMBL271956 | — | — | 1 | 5.52 |
| CHEMBL411326 | — | — | 1 | 5.29 |
| CHEMBL261604 | — | — | 1 | 5.28 |
| CHEMBL180650 | — | — | 1 | 5.24 |
| CHEMBL270348 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408218 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL412099 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL261386 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL406392 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL273089 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL411327 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL407548 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL406679 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL270094 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL405474 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL272424 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL408965 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL270347 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL270095 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL271956 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL411326 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL261604 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL180650 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL270348 | — | IC50 | = | 9800.0 | nM | 5.01 |