Assay Detail
Functional
CHEMBL945871
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Inhibition of IL-1-beta-stimulated PGE2 production in human A549 cells in presence of 2% fetal bovine serum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.57 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272424 | — | — | 1 | 6.68 |
| CHEMBL180650 | — | — | 1 | 6.57 |
| CHEMBL270347 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272424 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL180650 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL270347 | — | IC50 | = | 350.0 | nM | 6.46 |