Assay Detail
Binding
CHEMBL945894
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Inhibition of MAOA
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Multi-target-directed ligands to combat neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.79 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258420 | — | — | 1 | 7.43 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.39 |
| CHEMBL158946 | — | — | 1 | 6.27 |
| CHEMBL109018 | — | — | 1 | 5.95 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 5.92 |
| CHEMBL255700 | — | — | 1 | 5.62 |
| CHEMBL356385 | — | — | 1 | 4.70 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.07 |
| CHEMBL257368 | — | — | 1 | - |
| CHEMBL255230 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258420 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL887 | RASAGILINE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL158946 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL109018 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL972 | SELEGILINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL255700 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL356385 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL257368 | — | IC50 | = | 299800.0 | nM | - |
| CHEMBL255230 | — | IC50 | = | 375000.0 | nM | - |