Assay Detail
Binding
CHEMBL945895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAOB
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Multi-target-directed ligands to combat neurodegenerative diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.27 | 8.48 |
| Ki | 1 | 7.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109018 | — | — | 1 | 8.48 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.36 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 8.15 |
| CHEMBL258420 | — | — | 1 | 7.24 |
| CHEMBL26138 | — | — | 1 | 7.16 |
| CHEMBL356385 | — | — | 1 | 5.82 |
| CHEMBL255700 | — | — | 1 | 5.37 |
| CHEMBL255230 | — | — | 1 | 4.50 |
| CHEMBL158946 | — | — | 1 | 4.29 |
| CHEMBL257368 | — | — | 1 | 4.19 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109018 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL887 | RASAGILINE | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL972 | SELEGILINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL258420 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL26138 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL356385 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL255700 | — | IC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL255230 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL158946 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL257368 | — | IC50 | = | 64200.0 | nM | 4.19 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 120000.0 | nM | - |