Assay Detail
Binding
CHEMBL945937
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Inhibition of human JAK2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272424 | — | — | 1 | 9.70 |
| CHEMBL412099 | — | — | 1 | 7.00 |
| CHEMBL270347 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272424 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL412099 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL270347 | — | IC50 | = | 900.0 | nM | 6.05 |