Assay Detail
Binding
CHEMBL945966
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Inhibition of HIV integrase strand transfer activity
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.28 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254524 | — | — | 1 | 7.89 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 7.57 |
| CHEMBL254318 | — | — | 1 | 7.55 |
| CHEMBL209854 | — | — | 1 | 7.30 |
| CHEMBL402290 | — | — | 1 | 7.21 |
| CHEMBL254522 | — | — | 1 | 7.15 |
| CHEMBL254317 | — | — | 1 | 7.00 |
| CHEMBL254523 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254524 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL254318 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL209854 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL402290 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL254522 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL254317 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL254523 | — | IC50 | = | 265.0 | nM | 6.58 |