Assay Detail
Functional
CHEMBL945976
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.09 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253716 | — | — | 1 | 7.66 |
| CHEMBL253508 | — | — | 1 | 7.52 |
| CHEMBL253715 | — | — | 1 | 7.50 |
| CHEMBL404523 | — | — | 1 | 7.44 |
| CHEMBL404321 | — | — | 1 | 7.36 |
| CHEMBL439424 | — | — | 1 | 7.30 |
| CHEMBL252504 | — | — | 1 | 7.09 |
| CHEMBL253717 | — | — | 1 | 6.90 |
| CHEMBL267856 | — | — | 1 | 6.88 |
| CHEMBL404522 | — | — | 1 | 6.74 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.60 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253716 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL253508 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL253715 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL404523 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL404321 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL439424 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL252504 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL253717 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL267856 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL404522 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 755.0 | nM | 6.12 |