Assay Detail
ADMET
CHEMBL945977
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Cytotoxicity against HUVEC cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.47 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253717 | — | — | 1 | 7.46 |
| CHEMBL404522 | — | — | 1 | 7.09 |
| CHEMBL253715 | — | — | 1 | 6.94 |
| CHEMBL253508 | — | — | 1 | 6.81 |
| CHEMBL439424 | — | — | 1 | 6.79 |
| CHEMBL267856 | — | — | 1 | 6.21 |
| CHEMBL252504 | — | — | 1 | 6.17 |
| CHEMBL253716 | — | — | 1 | 6.10 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.93 |
| CHEMBL404523 | — | — | 1 | 5.93 |
| CHEMBL404321 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253717 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL404522 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL253715 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL253508 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL439424 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL267856 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL252504 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL253716 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL404523 | — | IC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL404321 | — | IC50 | = | 2042.0 | nM | 5.69 |