Assay Detail

CHEMBL946025

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Binding

Binding affinity to human vasopressin V2 receptor

ChEMBL ↗

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Target

Vasopressin V2 receptor (CHEMBL1790) ↗

Open DB target context

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Vasopressin V2 receptor (CHEMBL1790) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Vasopressin V2 receptor

CHEMBL1790

Anchored from Assay target.

Protein identity Vasopressin V2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Vasopressin V2 receptor (CHEMBL1790) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

The discovery of GSK221149A: a potent and selective oxytocin antagonist.

Liddle J, Allen MJ, Borthwick AD, Brooks DP, Davies DE, Edwards RM, Exall AM, Hamlett C, Irving WR, Mason AM, McCafferty GP, Nerozzi F, Peace S, Philp J, Pollard D, Pullen MA, Shabbir SS, Sollis SL, Westfall TD, Woollard PM, Wu C, Hickey DM.
Bioorg Med Chem Lett (2008) 18 : 90 -94
PubMed 18032036 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	6.25	6.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL382301	ATOSIBAN	4.0	1	6.48
CHEMBL429736	RETOSIBAN	3.0	1	6.02

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL382301	ATOSIBAN	Ki	=	330.0	nM	6.48
CHEMBL429736	RETOSIBAN	Ki	=	950.0	nM	6.02