Assay Detail
Functional
CHEMBL946513
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Antileishmanial activity against Leishmania major promastigotes assessed as inhibition of [3H]thymidine uptake after 2 hrs by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.04 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.80 |
| CHEMBL485479 | — | — | 1 | 4.75 |
| CHEMBL187460 | CRYPTOTANSHINONE | — | 1 | 4.74 |
| CHEMBL519694 | — | — | 1 | 4.59 |
| CHEMBL485279 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL485479 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL187460 | CRYPTOTANSHINONE | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL519694 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL485279 | — | IC50 | = | 46700.0 | nM | 4.33 |