Assay Detail
Binding
CHEMBL946589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Saccharomyces cerevisiae NMT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glycylpeptide N-tetradecanoyltransferase (CHEMBL5484) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6269 | SC-58272 | — | 1 | 7.62 |
| CHEMBL448516 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6269 | SC-58272 | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL448516 | — | IC50 | = | 50.0 | nM | 7.30 |