Assay Detail
Functional
CHEMBL946685
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Cytotoxicity against human Bel7402 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.69 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 5.26 |
| CHEMBL474595 | — | — | 1 | 5.18 |
| CHEMBL482316 | — | — | 1 | 4.99 |
| CHEMBL472582 | — | — | 1 | 4.81 |
| CHEMBL133714 | BENZYL CAFFEATE | — | 1 | 4.76 |
| CHEMBL482354 | — | — | 1 | 4.55 |
| CHEMBL482317 | — | — | 1 | 4.54 |
| CHEMBL471973 | — | — | 1 | 4.35 |
| CHEMBL482353 | — | — | 1 | 4.24 |
| CHEMBL481644 | — | — | 1 | 4.22 |
| CHEMBL480395 | — | — | 1 | - |
| CHEMBL480927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL474595 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL482316 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL472582 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL133714 | BENZYL CAFFEATE | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL482354 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL482317 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL471973 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL482353 | — | IC50 | = | 58100.0 | nM | 4.24 |
| CHEMBL481644 | — | IC50 | = | 59700.0 | nM | 4.22 |
| CHEMBL480395 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL480927 | — | IC50 | > | 300000.0 | nM | - |