Assay Detail
Functional
CHEMBL946686
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Cytotoxicity against human MCF7 cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.68 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471973 | — | — | 1 | 5.23 |
| CHEMBL481644 | — | — | 1 | 4.91 |
| CHEMBL482353 | — | — | 1 | 4.89 |
| CHEMBL133714 | BENZYL CAFFEATE | — | 1 | 4.85 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.57 |
| CHEMBL482316 | — | — | 1 | 4.54 |
| CHEMBL472582 | — | — | 1 | 4.52 |
| CHEMBL482317 | — | — | 1 | 4.39 |
| CHEMBL474595 | — | — | 1 | 4.21 |
| CHEMBL482354 | — | — | 1 | - |
| CHEMBL480395 | — | — | 1 | - |
| CHEMBL480927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471973 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL481644 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL482353 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL133714 | BENZYL CAFFEATE | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL482316 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL472582 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL482317 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL474595 | — | IC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL482354 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL480395 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL480927 | — | IC50 | > | 300000.0 | nM | - |