Assay Detail
Binding
CHEMBL946771
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Inhibition of ErbB4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor tyrosine-protein kinase erbB-4 (CHEMBL3009) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507714 | — | — | 1 | 7.13 |
| CHEMBL448929 | — | — | 1 | 6.85 |
| CHEMBL466397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507714 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL448929 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL466397 | — | IC50 | > | 25000.0 | nM | - |