Assay Detail
Binding
CHEMBL946773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of B-raf V600E mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.80 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507714 | — | — | 1 | 7.10 |
| CHEMBL448929 | — | — | 1 | 6.50 |
| CHEMBL466397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507714 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL448929 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL466397 | — | IC50 | > | 2000.0 | nM | - |