Assay Detail
Functional
CHEMBL946969
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Antiproliferative activity against human SKBR3 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.04 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.70 |
| CHEMBL152543 | — | — | 1 | 6.96 |
| CHEMBL152133 | — | — | 1 | 6.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.10 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.06 |
| CHEMBL347068 | — | — | 1 | 6.06 |
| CHEMBL346525 | — | — | 1 | 5.89 |
| CHEMBL272052 | — | — | 1 | 5.47 |
| CHEMBL407420 | — | — | 1 | 5.46 |
| CHEMBL272240 | — | — | 1 | 5.44 |
| CHEMBL260530 | — | — | 1 | 5.41 |
| CHEMBL260738 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL152543 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL152133 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL347068 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL346525 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL272052 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL407420 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL272240 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL260530 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL260738 | — | IC50 | = | 6900.0 | nM | 5.16 |