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Assay Detail

CHEMBL946970

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Functional
Antiproliferative activity against human MKN45 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MKN-45
Confidence 1 — Organism
Curated By Autocuration

Target

MKN-45 (CHEMBL614354)
Type CELL-LINE
Organism Homo sapiens

Publication

Histone deacetylase inhibitors: from bench to clinic.
Paris M, Porcelloni M, Binaschi M, Fattori D.
J Med Chem (2008) 51 : 1505 -1529
PubMed 18247554 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.97 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 7.00
CHEMBL217004 1 6.92
CHEMBL386473 1 6.70
CHEMBL426343 1 6.64
CHEMBL218511 1 6.55
CHEMBL216625 1 6.43
CHEMBL384961 1 6.26
CHEMBL217098 1 6.25
CHEMBL217716 1 6.20
CHEMBL217468 1 6.12
CHEMBL152543 1 6.10
CHEMBL152133 1 6.08
CHEMBL385406 1 6.08
CHEMBL218514 1 5.82
CHEMBL386135 1 5.75
CHEMBL218080 1 5.66
CHEMBL216359 1 5.54
CHEMBL347068 1 5.44
CHEMBL27759 ENTINOSTAT 3.0 1 5.38
CHEMBL217604 1 5.35
CHEMBL218236 1 5.34
CHEMBL346525 1 5.30
CHEMBL216885 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 100.0 nM 7.00
CHEMBL217004 IC50 = 120.0 nM 6.92
CHEMBL386473 IC50 = 200.0 nM 6.70
CHEMBL426343 IC50 = 230.0 nM 6.64
CHEMBL218511 IC50 = 280.0 nM 6.55
CHEMBL216625 IC50 = 370.0 nM 6.43
CHEMBL384961 IC50 = 550.0 nM 6.26
CHEMBL217098 IC50 = 560.0 nM 6.25
CHEMBL217716 IC50 = 630.0 nM 6.20
CHEMBL217468 IC50 = 750.0 nM 6.12
CHEMBL152543 IC50 = 800.0 nM 6.10
CHEMBL152133 IC50 = 830.0 nM 6.08
CHEMBL385406 IC50 = 840.0 nM 6.08
CHEMBL218514 IC50 = 1500.0 nM 5.82
CHEMBL386135 IC50 = 1800.0 nM 5.75
CHEMBL218080 IC50 = 2190.0 nM 5.66
CHEMBL216359 IC50 = 2910.0 nM 5.54
CHEMBL347068 IC50 = 3640.0 nM 5.44
CHEMBL27759 ENTINOSTAT IC50 = 4160.0 nM 5.38
CHEMBL217604 IC50 = 4500.0 nM 5.35
CHEMBL218236 IC50 = 4540.0 nM 5.34
CHEMBL346525 IC50 = 4980.0 nM 5.30
CHEMBL216885 IC50 = 31500.0 nM 4.50