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Assay Detail

CHEMBL946975

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC1
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Histone deacetylase 1 (CHEMBL325)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Histone deacetylase inhibitors: from bench to clinic.
Paris M, Porcelloni M, Binaschi M, Fattori D.
J Med Chem (2008) 51 : 1505 -1529
PubMed 18247554 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 6.15 8.74
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL403323 1 8.74
CHEMBL98 VORINOSTAT 4.0 1 7.68
CHEMBL235842 1 7.40
CHEMBL260959 1 7.35
CHEMBL402363 AZUMAMIDE E 1 7.30
CHEMBL272401 1 7.26
CHEMBL27759 ENTINOSTAT 3.0 1 6.75
CHEMBL254110 1 6.52
CHEMBL272841 1 6.22
CHEMBL270249 1 6.16
CHEMBL272980 MOCETINOSTAT 2.0 1 6.09
CHEMBL270097 1 6.00
CHEMBL271102 1 5.82
CHEMBL211926 1 5.70
CHEMBL258813 1 5.70
CHEMBL211625 1 5.70
CHEMBL241337 1 5.70
CHEMBL378942 1 5.70
CHEMBL407849 1 5.52
CHEMBL214271 1 5.52
CHEMBL375409 1 5.52
CHEMBL379516 1 5.52
CHEMBL384503 1 5.40
CHEMBL269908 1 5.40
CHEMBL379635 1 5.40
CHEMBL211320 1 5.40
CHEMBL209762 1 5.40
CHEMBL209729 1 5.40
CHEMBL406800 1 -
CHEMBL270887 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL403323 IC50 = 1.8 nM 8.74
CHEMBL98 VORINOSTAT IC50 = 21.0 nM 7.68
CHEMBL235842 IC50 = 40.0 nM 7.40
CHEMBL260959 IC50 = 45.0 nM 7.35
CHEMBL402363 AZUMAMIDE E IC50 = 50.0 nM 7.30
CHEMBL272401 IC50 = 55.0 nM 7.26
CHEMBL27759 ENTINOSTAT IC50 = 180.0 nM 6.75
CHEMBL254110 IC50 = 300.0 nM 6.52
CHEMBL272841 IC50 = 600.0 nM 6.22
CHEMBL270249 IC50 = 700.0 nM 6.16
CHEMBL272980 MOCETINOSTAT IC50 = 820.0 nM 6.09
CHEMBL270097 IC50 = 1000.0 nM 6.00
CHEMBL271102 IC50 = 1500.0 nM 5.82
CHEMBL211926 IC50 = 2000.0 nM 5.70
CHEMBL258813 IC50 = 2000.0 nM 5.70
CHEMBL211625 IC50 = 2000.0 nM 5.70
CHEMBL241337 IC50 = 2000.0 nM 5.70
CHEMBL378942 IC50 = 2000.0 nM 5.70
CHEMBL407849 IC50 = 3000.0 nM 5.52
CHEMBL214271 IC50 = 3000.0 nM 5.52
CHEMBL375409 IC50 = 3000.0 nM 5.52
CHEMBL379516 IC50 = 3000.0 nM 5.52
CHEMBL384503 IC50 = 4000.0 nM 5.40
CHEMBL269908 IC50 = 4000.0 nM 5.40
CHEMBL379635 IC50 = 4000.0 nM 5.40
CHEMBL211320 IC50 = 4000.0 nM 5.40
CHEMBL209762 IC50 = 4000.0 nM 5.40
CHEMBL209729 IC50 = 4000.0 nM 5.40
CHEMBL406800 Activity - -
CHEMBL270887 IC50 > 100.0 nM -