Assay Detail
Binding
CHEMBL946979
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Inhibition of human HDAC1
40
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.95 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409847 | — | — | 1 | 9.00 |
| CHEMBL270739 | — | — | 1 | 8.02 |
| CHEMBL247183 | — | — | 1 | 7.94 |
| CHEMBL410636 | — | — | 1 | 7.89 |
| CHEMBL271799 | — | — | 1 | 7.75 |
| CHEMBL270740 | — | — | 1 | 7.60 |
| CHEMBL271798 | — | — | 1 | 7.60 |
| CHEMBL406650 | — | — | 1 | 7.58 |
| CHEMBL272615 | — | — | 1 | 7.58 |
| CHEMBL247184 | — | — | 1 | 7.51 |
| CHEMBL270893 | — | — | 1 | 7.44 |
| CHEMBL279797 | — | — | 1 | 7.44 |
| CHEMBL272614 | — | — | 1 | 7.39 |
| CHEMBL261610 | — | — | 1 | 7.33 |
| CHEMBL429429 | — | — | 1 | 7.28 |
| CHEMBL272403 | — | — | 1 | 7.26 |
| CHEMBL272401 | — | — | 1 | 7.26 |
| CHEMBL405504 | — | — | 1 | 7.12 |
| CHEMBL272402 | — | — | 1 | 7.10 |
| CHEMBL270098 | — | — | 1 | 7.10 |
| CHEMBL259027 | — | — | 1 | 6.97 |
| CHEMBL261829 | — | — | 2 | 6.85 |
| CHEMBL270476 | — | — | 1 | 6.80 |
| CHEMBL269890 | — | — | 1 | 6.72 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.70 |
| CHEMBL387224 | — | — | 1 | 6.70 |
| CHEMBL245556 | — | — | 1 | 6.69 |
| CHEMBL387015 | — | — | 1 | 6.66 |
| CHEMBL272840 | — | — | 1 | 6.32 |
| CHEMBL218129 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409847 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270739 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL247183 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL410636 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL271799 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL270740 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL271798 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL406650 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL272615 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL247184 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL279797 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL270893 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL272614 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL261610 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL429429 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL272403 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL272401 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL405504 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL272402 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL270098 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL259027 | — | IC50 | = | 106.5 | nM | 6.97 |
| CHEMBL261829 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL270476 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL269890 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL387224 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL245556 | — | IC50 | = | 203.5 | nM | 6.69 |
| CHEMBL387015 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL272840 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL218129 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL271767 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL217035 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL412598 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL245946 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL216336 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL260958 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL261829 | — | IC50 | = | 1069.5 | nM | 5.97 |
| CHEMBL260740 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL260957 | — | IC50 | = | 3000.0 | nM | 5.52 |